This special issue of the George Wright Forum examines past and current practice in landscape-scale conservation; a common thread is that the National Park Service (NPS) has a role in all of our examples. Articles in the issue stress the importance of working at scale and taking an expansive, landscape view. The Landscape Conservation Cooperatives are highlighted, as is the national heritage areas program. Case studies are offered on emerging landscape conservation initiatives along the Appalachian Trail and in the Chesapeake watershed, and the Network for Landscape Conservation is highlighted as well.